| Time | Lecture / Talk | Author / Institution | Additional Info |
|---|---|---|---|
| 08:00 |
Registration of the Participants
|
- | - |
| 08:30 – 09:00 |
Opening Ceremony
|
- | Hall I |
| 09:00 – 09:30 |
Plenary Lecture
Pioneering Sesquiterpenoid Chemodiversity in Artemisia hedinii
Abstract: Natural products remain a privileged source of new therapeutics, yet their clinical translation hinges on precise structural and stereochemical assignment. Here, we describe our ongoing investigation of Artemisia hedinii, an annual herb long used in Chinese folk medicine for detoxification and inflammation relief. Phytochemical re-investigation of A. hedinii has now delivered a total of 107 sesquiterpenoids, comprising 81 previously undescribed metabolites. Among these, six unprecedented carbon skeletons were identified. Unambiguous determination of absolute configuration was achieved by an integrated strategy: high-resolution MS, 1D and 2D-NMR spectra, single-crystal X-ray diffraction, TDDFT ECD calculations, DFT NMR chemical-shift fitting, and biomimetic total syntheses that delivered all new-skeleton prototypes as single enantiomers. Biological evaluation revealed potent anti-hepatic-fibrosis activity in human LX-2 hepatic stellate cells, with some compounds significantly suppressing α-SMA expression. Concurrent assays in LPS-stimulated RAW264.7 macrophages and bone-marrow-derived macrophages (BMDM) demonstrated dose-dependent inhibition of NO, IL-6 and TNF-α release, underscoring broad anti-inflammatory potential. Collectively, these findings expand the chemical space of the Artemisia chemodiversity atlas and establish A. hedinii as a prolific reservoir of architecturally novel, bioactive sesquiterpenoids for drug discovery against inflammation and fibrosis. |
Prof. Dr. Ye Yang, Shanghai Institute of Materia Medica, Shanghai, China | Hall I Chair: Dr. Nenad Janković |
| 09:30 – 10:00 |
Plenary Lecture
Next-generation hydraulic fluids: the role and potential of protic
ionic liquids
Abstract: This work presents experimental findings from a comprehensive study on protic ionic liquid (PIL)–water mixtures, focusing on 2-hydroxypropylammonium formate (HPF). These systems were explored as next-generation, environmentally friendly hydraulic fluids. The study involved extensive physical and chemical characterization, including density, viscosity, thermal conductivity, electrical conductivity, and specific heat capacity. In addition, the fluids were tested under standard conditions for compatibility with filter materials, foaming behavior, and copper corrosion resistance. Rheological measurements and flow curve modeling were used to evaluate shear behavior. The findings confirm that HPF–water mixtures can meet ISO VG viscosity standards and offer high thermal efficiency, stability, and safety, making them strong candidates for sustainable hydraulic applications. |
Prof. Dr. Milan Vraneš, Faculty of Science, University of Novi Sad, Serbia | Hall I Chair: Dr. Nenad Janković |
| 10:00 – 10:30 |
Coffee Break
|
- | - |
| 10:30 – 11:00 |
Section Lecture
Graph-based modeling of diabetic patient data for readmission risk
and care pattern analysis
Abstract: Electronic health records (EHRs) contain rich
relational data such as individual patient data, encounters,
diagnoses, medications, etc. Healthcare systems often store EHR
data in tabular form. However, traditional flat representations
(“bag of features”) can lose critical context. For example,
treating a patient encounter as an unordered set of codes obscures
the fact that a specific combination of drugs might have caused an
adverse outcome. Knowledge graphs offer a robust alternative by
organizing medical data into interconnected entities and
relationships, capturing complex associations (e.g. between
symptoms, treatments, diagnoses) for a more holistic understanding
of patient history. In this work, we transform the Diabetes 130-US
Hospitals dataset (a collection of ~100,000 inpatient encounters
from 130 hospitals over 10 years) into a labeled property graph
(LPG), and demonstrate the advantages both conceptual and
quantitative of graph-based analysis, in a medical informatics
context. Each encounter in this dataset includes patient
demographics, diagnoses (ICD-9 codes), lab results (e.g. HbA1c),
and 24 diabetes-related medications with change indicators (“up”,
“down”, “steady” or “no change”) among other features. Notably,
the original study focused on 30-day readmissions, highlighting
that poor glycemic control and suboptimal inpatient diabetes
management lead to higher readmission rates and complications. Our
graph model makes these clinical relationships explicit, enabling
multi-hop reasoning (e.g. linking a patient’s lab result to
medication changes and subsequent readmission outcome) that is
cumbersome with relational tables. We show that converting such
EHR data into a graph can improve predictive modeling of
readmissions and uncover insightful patterns of comorbidities and
care processes that would be difficult to extract using SQL alone,
aligning with recent trends in biomedical informatics to leverage
networks for clinical data analysis.
|
Dr. Miloš Jovičić, Institute for Information Technologies, Kragujevac | Hall I Chair: Dr. Vladimir Simić |
| 10:30 – 11:00 |
Section Lecture
Evaluation of the Carcinogen-Scavenging Activity of Polyphenolic
Compounds by Using Quantum Mechanics-Based Protocol QM-CSA
Abstract: This study explored the chemopreventive potential of (+)-catechin, rosmarinic acid, and gnaphaliin, prominent phenolic compounds found in Rosmarinus officinalis L., cocoa, and Helichrysum italicum, respectively, against the carcinogenic effects of aflatoxin B1 exo-8,9-epoxide (AFBO), a genotoxic metabolite of naturally occurring mycotoxin aflatoxin B1 (AFB1). Activation free energy (∆G⧧) values for the studied reactions were determined using density functional theory (DFT) with the M11-L and MN12-L functionals, the 6-311++G(d,p) flexible basis set, and the implicit Solvation Model Density (SMD). These calculations followed our recently established quantum mechanics-based protocol for carcinogen scavenging activity (QM-CSA). The computational findings indicated that the activation free energy for the reaction of (+)-catechin, rosmarinic acid, and gnaphaliin with AFBO is notably lower than that of the reaction between AFBO and guanine (by 1.86 kcal/mol - 11.54 kcal/mol). The carcinogen scavenging activity (CSA) among the studied polyphenols, relative to guanine and glutathione, was found to follow the order: gnaphaliin > (+)-catechin > rosmarinic acid. This suggests that studied polyphenols serve as effective natural scavengers of AFBO, potentially inhibiting the formation of DNA adducts associated with AFB1. |
Prof. Dr. Veronika Furlan, University of Maribor, Slovenia | Hall II Chair: Dr. Marko Antonijević |
| 11:00 – 13:00 |
Session BE.T1. Biomedical engineering (Oral session)
BE.T1.1 – Effect of Gradient Magnetic Fields on
Molecular Diffusion Through Cell Membranes: A Theoretical and
Numerical Study
BE.T1.2 – Simulating the behaviour of cancer
cells in the microfluidic chip
BE.T1.3 – Harnessing Hydrolized Silk Fibroin in
Electrospun Nanofibers for Biomedical Applications
BE.T1.4 – Integration of 3D Printing
Technologies with Deuterated Polyunsaturated Fatty Acids
(D-PUFAs)
BE.T1.5 – AI based Prediction Model and
Influential Factors for Hypersensitivity in Dental Implants made
of Ti alloys
BE.T1.6 – In Vivo Models for Spinal Disc
Regeneration
BE.T1.7 – Time-dependent apoptotic responses to
vitamin E in precancerous lesions-on-chip models
BE.T1.8 – The Effect of Dulbecco’s ‘Eagle’
Medium on the Mass and Tribological Characteristics of PLA
Samples: A Preliminary Study |
- | Chair: Dr. Vladimir Simić |
| 11:00 – 13:00 |
Session AST.T1. Applied Science and Technologies (Poster session)
AST.T1.1 – Algal-derived chromopeptides:
Alternatives to fetal bovine serum in cellular agriculture
AST.T1.2 – A Survey of Reinforcement Learning
Approaches for Tuning Particle Swarm Optimization
AST.T1.3 – Experimental study on a
phase-change-material-based thermal management scheme coupled
with external fins for lithium-ion battery
AST.T1.4 – Mercury removal from acid mine
drainage by natural pyrophyllite schist material
AST.T1.5 – Comprehensive Study on the Impact of
Low-Temperature Environments on the Performance and Safety of
Lithium-Ion Batteries
AST.T1.6 – Protic Ionic Liquid–Water
Interactions: A Combined Experimental and Simulation Study on
2-Hydroxypropylammonium Formate
AST.T1.7 – Research on the Performance of Power
Batteries in High-Temperature and High-Humidity Environments
AST.T1.8 – Petrography of high-pH fluids
sedimentary assemblages and biotechnological potential of
sediment Bacillus
AST.T1.9 – Characterization of copper
electrodeposited onto palladium from ethaline
AST.T1.10 – Influence of Methyl Salicylate on
the Solubility and Self-Association of Caffeine: A Thermodynamic
and Simulation Study
AST.T1.11 – Preliminary investigation of
natural radioactivity (Gross Alpha/Beta) in rural water supplies
of Bagerhat district, Bangladesh
AST.T1.12 – Bending Analysis of FGM Plates on a
Kerr Foundation Using an HSDT Shape Function
AST.T1.13 – Economic Growth, Renewable Energy,
Trade Openness and CO2 Emissions: A Causality Analysis
AST.T1.14 – Sustainable Activated Carbon:
Transforming Sawdust with Zinc Chloride Activation Treatment
AST.T1.15 – Effects of the Sustainable Tourism
Concept, Environmental Beliefs, and Social Media Influencers on
the Choice of Green Hotels When Traveling
AST.T1.16 – Chemical analysis of soil and
determination of its fertility
AST.T1.17 – Content of air pollutants in
Kraljevo
AST.T1.18 – Synthesis and characterization of
cerium salt of 12-tungstophosphoric heteropoly acid – Ce-PWA
AST.T1.19 – Correlation analysis of heavy
metals, radionuclides, and physicochemical properties in soil
from Serbia
AST.T1.20 – From Waste to Resource:
Sawdust-Based Activated Carbons for Cadmium-ion Adsorption
AST.T1.21 – Reusability potential of
Ambrosia-based biosorbents for Crystal Violet dye removal
AST.T1.22 – Niobium electrodeposition from
chloroaluminate based molten salts containing niobium ions
AST.T1.23 – When Does Trade Become Green?
AST.T1.24 – Kinetic study of Re(VII) removal
from aqueous solutions by macroporous magnetic nanocomposite
AST.T1.25 – The new ionic additives for safer
and durable electrolytes in lithium-ion batteries
AST.T1.26 – Investigation of Briggs-Rauscher
Oscillograms via Peak Area Integration
AST.T1.27 – Intracellular effect of synergistic
action of N-TiO2 nanoparticles and blue light on HeLa cervical
cancer cells: Raman spectroscopic study
AST.T1.28 – Electrospun Polysaccharide Fiber
Stabilization: An In-Situ Green Crosslinking Approach
AST.T1.29 – MRI-only Radiotherapy Dose Planning
via CycleGAN-Generated Synthetic CT
AST.T1.30 – The potential of tartarates as
compatibilizers and plasticizers in biodegradable films |
- | Chair: Dr. Marko Antonijević |
| 13:00 – 14:00 |
Buffet Lunch
|
- | - |
| 14:00 – 14:30 |
Plenary Lecture
Application of Hydrogel in Disease Therapy and Tissue Engineering
Abstract: Hydrogels are widely used for controlled drug release due to their biocompatibility, hydrophilicity, and drug-loading capacity. However, conventional hydrogels often show initial burst release followed by a decline, caused by high drug concentration gradients and uneven drug distribution. Here, we propose a multilayer sodium alginate hydrogel to improve drug release fluctuation. The drug is loaded into the inner hydrogel layers to optimize distribution, while the drug-free outer layer minimizes rapid surface desorption and reduces the concentration gradient. The system demonstrates excellent biocompatibility (>95% cell viability) and reduces the initial 2 h drug release rate by 67.4% compared to monolayer hydrogels, effectively stabilizing release fluctuations. |
Prof. Dr. Wei Zhang, Dalian University of Technology, Dalian, China | Hall I Chair: Dr. Miljan Milošević |
| 14:30 – 15:00 |
Plenary Lecture
Development of experimental set up for functional characterization
of materials of interest in biomedical imaging and/or photodynamic
therapy and/or drug delivery by reflection-mode frequency
photoacoustics
Abstract: Results of this work confirmed the successful adaptation of a cost-effective laser engraving system and a photoacoustic cell from an earlier generation spectroscopy unit into a frequency photoacoustic excitation and detection system. In parallel, sample systems were developed with thin layers of polymer-based protoporphyrin IX applied on thin films of Tungsten sputtered on a glass substrate. The described sample systems were recorded by the reflection-mode frequency photoacoustics. Tendencies in the formation of amplitude response have been successfully recorded, which are attributed to differences in thermo-optical properties and chemical composition of the observed samples. The results are interpreted in terms of the newly developed theoretical model of photoacoustic response of two-layered samples and have been proven to be in accordance with it. The results have been effectively correlated with the established theoretical model from the literature, which has not been used before in biomedical applications, thus laying the groundwork for applying the method to characterize diverse solid materials at different levels of transparency. This result has demonstrated the potential of the system to successfully record manifestations of various thermodynamic properties of the observed materials, allowing for ther functional characterization and potential application in biomedicine, i.e. the diagnostics and therapy of cancer. |
Dr. Mioljub Nešić, Institute for Nuclear Sciences “Vinca”, University of Belgrade, Serbia | Hall I Chair: Dr. Biljana Nikić |
| 15:00 – 15:30 |
Section Lecture
Effect of structural elements of tannins on their reactivity with
metal ions – experimental study with QM support
Abstract: Tannins are a wide group of natural polyphenols that are traditionally used for leather tanning. Nowadays, these compounds are also being researched for their antioxidative, anticarcinogenic and other health-beneficial properties. Among them is also their antibacterial activity. This is to a large extent ascribed to their ability to chelate metal ions and therefore deplete growth media of metal ions. However, studies that would enable a better understanding of these interactions are still relatively rare, mostly due to the difficulty of obtaining the pure compounds. Initially, the four compounds, namely vescalin, castalin, vescalagin and castalagin, were isolated using preparative reverse-phase C18 HPLC. Finally, the metal chelating ability of isolated compounds was examined using UV/Vis spectroscopy in conjunction with a Job plot. Because the interactions of tannins with metal ions are closely connected to the deprotonation of ellagitannins, the microscopic protolytic equilibrium of ellagitannins was examined. During the work, the DFT computations were used to get better elucidation of the obtained results on the molecular level, either for the explanation of the obtained chemical shifts or to search for the most probable binding positions of metal ions. |
Prof. Dr. Gregor Hostnik, Faculty of Chemistry and Chemical Technology, University of Maribor | Hall I Chair: Dr. Jelena Đorović Jovanović |
| 15:00 – 15:30 |
Section Lecture
Changes in protein expression in HeLa cervical cancer cells
induced by [Pd(dach)Cl2] Complex
Abstract: In this work, we have investigated the changes in protein expression in HeLa cervical cancer cells treated with [Pd(dach)Cl2]. This Pd(II) complex showed a mild cytotoxic effect on HeLa cells, enabling us to study quantitatively changes in the protein expression between control and treated cells. The comparative proteomics analysis is performed using label-free data-independent liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition to this, we employed a computational biology approach and the informational spectrum method (ISM) to predict potential protein interactors of the [Pd(dach)Cl2] complex in HeLa cells. Our results show 121 differentially abundant proteins between control and [Pd(dach)Cl2]-treated cells, and we showed that [Pd(dach)Cl2] targets proteins involved in ribosomal biogenesis and RNA splicing. On the other hand, theoretical prediction implies the potential effect of [Pd(dach)Cl2] on p53 (oncogenic protein) signalling pathway, and thus, alterations of the expression of regulatory proteins involved in cell survival and proliferation. Since this is a proof-of-concept study, the sample size was not adequate to perform multiple testing correction. However, the findings are in line with the existing literature on HeLa cells' protein and mRNA expression. Moreover, the observed down-regulation of several proteins highly correlated with tumour development and progression was consistent with the observed cytotoxic effect of [Pd(dach)Cl2] treatment. Although this confirms the validity of the reported results, further validation in the context of a statistically well-powered study is required. |
Dr. Marijana Petković, “Vinča" Institute of Nuclear Sciences, University of Belgrade | Hall II Chair: Doc. Dr. Snežana Papović |
| 15:30 – 17:00 |
Session CCMD.T1. Chemoinformatics, chemogenomics and molecular
design (Poster session)
CCMD.T1.1 – Computer-Aided Drug Design of novel
dual histone deacetylase inhibitors
CCMD.T1.2 – Theoretical insight into redox
properties of 9-Acridinyl amino acid derivatives
CCMD.T1.3 – Physicochemical and pharmacological
properties of fused bicyclic hydantoins
CCMD.T1.4 – Computer-Aided Design and Analysis
of Multifunctional Tetrahydrocannabinol Derivatives Targeting
Acetylcholinesterase as Potential Antioxidant Neuroprotectors
for Alzheimer’s Disease
CCMD.T1.5 – Multifunctional
Tetrahydrocannabinol Derivatives as Potential Antioxidant
Neuroprotectors: In Silico Targeting of Monoamine Oxidase B and
Catechol-O-Methyltransferase in Parkinson’s Disease Therapy
CCMD.T1.6 – Stacking interactions between two
hydroquinone molecules in crystal structures
CCMD.T1.7 – Consideration of electrophoretic
behavior of some imidazoline and α-adrenergic receptors ligands
using DFT approach
CCMD.T1.8 – A New 2-Benzofuran-Linked
Chalcone–Tamoxifen Combination for Targeting ER+ Breast
Cancer
CCMD.T1.9 – Contribution to Elucidating the
Mechanism of Antimicrobial Action of a Dinuclear Pt/Cu Complex
Against Enterococcus faecalis – In Silico Approach
CCMD.T1.10 – Virtual Screening of Polyphenolic
Compounds from Edible Plants for Potential Application in
Alzheimer’s Therapy
CCMD.T1.11 – Data mining from oscillatory
reactions perturbed by Usnic acid
CCMD.T1.12 – Evaluating the pharmacological
profile of angular triquinane type hydantoins
CCMD.T1.13 – Exploring beta blocking as a
possible mechanism of anticancer action of 2-thiohydantoins
CCMD.T1.14 – Structural and Electronic Response
of New Nitroaromatic Compounds to Solvent Polarity: A DFT
Study
CCMD.T1.15 – Application of molecular modeling
in predicting palliative features of HDAC4 PROTACs against
Spinal Muscular Atrophy
CCMD.T1.16 – Quantum Theory of Atoms In
Molecules Analysis of NH/O Hydrogen Bonds of Glycine Complexes
with a Water Molecule
CCMD.T1.17 – Anti-Metastatic Effects of
Chalcone Complex on Prostate Cancer and Prostate Cancer Stem
Cell-Like Cells
CCMD.T1.18 – In Silico investigation of
substitution mechanism at the Nickel carbonyl complex
CCMD.T1.19 – Chemometric modeling for
blood–brain-barrier permeability prediction of protein kinase
inhibitors |
- | Chair: Dr. Jelena Đorović Jovanović |
| 15:30 – 17:00 |
Session BBMC.T1. Bioorganic, bioinorganic, and medicinal chemistry
(Oral session)
BBMC.T1.1 – A systematic analysis of
intermolecular interactions of cytochrome P450s with their
ligands
BBMC.T1.2 – Investigation of the cytotoxic and
apoptotic effects of the newly synthesized benzofuran-linked
chalcone compounds in breast cancer
BBMC.T1.3 – Synthesis, Characterization and
Anticancer Potential of the Selected Biginelli Hybrids and Their
Nanocomposites
BBMC.T1.4 – Heterocyclic derivatives of
steroidal thiosemicarbazones and their in silico drug-likeness
prediction as potential anticancer agents
BBMC.T1.5 – A Reproducible Pipeline for
Preprocessing and Annotation of scRNA-seq Data Using Seurat and
Scanpy
BBMC.T1.6 – Limitations of coarse grain models
of actin filament on prediction of X-ray diffraction patterns in
contracting skeletal muscle
BBMC.T1.7 – Is the key to the disease in
antioxidants, immunity or something else? |
- | Chair: Doc. Dr. Snežana Papović |
| 20:00 |
Gala Dinner
|
| Time | Lecture / Talk | Author / Institution | Additional Info |
|---|---|---|---|
| 09:00 – 10:30 |
Session BAB.F1. Bioinformatics and Applied Biology (Poster
session)
BAB.F1.1 – Chromosomal instability in
peripheral blood lymphocytes of endometrial cancer patients:
impact of clinical and reproductive factors
BAB.F1.2 – Potpeć Reservoir ecosystem health:
An analysis based on the Index of Biotic Integrity (IBI)
BAB.F1.3 – Chemoinformatics analysis of protein
surface amino acid composition
BAB.F1.4 – Computational examination of the
phenolic compounds binding to the Carbon Quantum Dots model
BAB.F1.5 – Reversing Death in Lung Cancer:
Epigenetic Control Mechanisms Underlying Anastasis
BAB.F1.6 – Transcriptomic Insights into Gene
and miRNA Dynamics Shaping EMT in Multiple Myeloma
BAB.F1.7 – An Enhanced Method for Quantifying
Energy Loss due to Diffusion in Coronary Arteries with
Stenosis
BAB.F1.8 – The Impact of Age on Non-Small Cell
Lung Cancer: A Comprehensive Overview
BAB.F1.9 – Bioinformatics tools in molecular
oncology
BAB.F1.10 – Identification of ADARB1 non-coding
transcripts as potential diagnostic biomarkers for colon
adenocarcinoma
BAB.F1.11 – Evaluation of the anticancer and
antibiofilm properties of Agrimonia eupatoria L. silver
nanoparticles
BAB.F1.12 – Assessment of Antibiotic Resistance
in Waterborne Pathogens
BAB.F1.13 – Unveiling the Multi-Target
Therapeutic Potential of Resveratrol Against Alzheimer’s
Disease: An Integrative Network Pharmacology and Molecular
Simulation Approach
BAB.F1.14 – A Multi-Omics Bioinformatic
Profiling of Epithelial-to-Mesenchymal Transition Following
Anastasis in Lung Adenocarcinoma Cells
BAB.F1.15 – Transcriptomic and Network-Based
Analysis of Autophagy Signaling Pathways in Bortezomib
Resistance in Multiple Myeloma
BAB.F1.16 – Identification of potential
microRNA biomarkers for early diagnosis of hepatocellular
carcinoma applying bioinformatics approaches
BAB.F1.17 – Prediction of the Biological
Activity of Compounds on the 11β-HSD2 Enzyme Using Different
Machine Learning Approaches
BAB.F1.18 – Inspection of meat for
trichinellosis. Classification of Trichinella spiralis using a
convolutional neural network
BAB.F1.19 – Length–weight relationship of brown
trout in selected rivers of the West Morava River system
(Serbia)
BAB.F1.20 – Bioinformatics analysis of prostate
cancer-related microRNA panel miR-141-3p, miR-21-5p and
miR-375-3p
BAB.F1.21 – Bioinformatics analysis of
microRNAs derived from HTR-8/SVneo potentially targeting BCL2 in
ovarian cancer cell line A2780
BAB.F1.22 – Numerical Modeling of Tumor Growth
using Solid Murine 3D Finite Element Model
BAB.F1.23 – Semantic segmentation of chest
computed tomography scans for quantifying pathologically altered
lung parenchyma in patients with post-COVID syndrome
BAB.F1.24 – Development of biocompatible
polyurethanes as functional biomaterials for advanced wound
healing applications
BAB.F1.25 – Coupled agent-based and finite
element modelling of cancer cell behavior
BAB.F1.26 – Structural Vulnerability of J-J
Stents to Radiotherapy in Cervical Cancer Patients: Implications
for Treatment Planning
BAB.F1.27 – Exploring
(Alkyl-ω-ol)triphenyltin(IV) Compounds as Renin Inhibitors:
Numerical modelling of diffusion process within finite element
liver model
BAB.F1.28 – FOTELP-VOX-GA: Integrating Genetic
Algorithms into Monte Carlo Dose Calculation for Prostate
Cancer |
- |
Hall II Chair: Dr. Bogdan Milićević |
| 10:30 – 12:00 |
Session BBMC.F1. Bioorganic, bioinorganic, and medicinal chemistry
(Poster session)
BBMC.F1.1 – Mechanochemical syntheses of Ru(II)
complexes with isothiazole-type of ligand
BBMC.F1.2 – Synthesis, characterization, and
antifungal activities of novel ferrocenyl pyrazolines containing
sulfonamide moiety
BBMC.F1.3 – Quantification of phenols,
flavonoids, and sugars in two medicinal fungi: Fomes fomentarius
(L.) and Schizophyllum commune (Fr.)
BBMC.F1.4 – Mineral content of honey from
Serbia: analysis of essential and toxic elements
BBMC.F1.5 – Flavonoids from Thymus vulgaris and
Thymus serpyllum and their antioxidative activity
BBMC.F1.6 – UHPLC-DAD-MS/MS phytochemical
profiling of Geranium robertianum L. herba extract obtained by
ultrasound-assisted extraction
BBMC.F1.7 – Synthesis and characterization of
new Schiff bases with thiocarbohydrazide and some aromatic
aldehydes and determination of their antioxidant potential
BBMC.F1.8 – EPR-based evaluation of antioxidant
properties of novel Schiff bases
BBMC.F1.9 – Study of host–guest interaction
between β-cyclodextrin and chromeno-pyrimidine derivative
BBMC.F1.10 – Caffeine in deutero water: solvent
isotope effect on hydration properties
BBMC.F1.11 – MADE-supported virtual screening
for small-molecule furin inhibitors
BBMC.F1.12 – Synthesis and structural
characteristics of silver(I) complex with
N-benzylthiabendazole
BBMC.F1.13 – The amino acid and fatty acid
composition and antioxidant activity of functional snack
products
BBMC.F1.14 – Crystallographic,
quantum-chemical, and biomolecular interaction study of a
europium(III) complex with pyridoxal-semicarbazone ligand
BBMC.F1.15 – Targeting thyroid cancer: in vitro
analysis of a benzofuran-substituted chalcone compound
BBMC.F1.16 – Binding interactions of
Biginelli-type compounds with serum albumin and DNA
BBMC.F1.17 – Biomolecular interactions of novel
Ruthenium(II) complexes with human serum albumin
BBMC.F1.18 – In silico evaluation of
drug-likeness properties of steroidal semicarbazones and
steroidal oxazolo[4.5-b]quinoxalines
BBMC.F1.19 – Evaluating the ADMET properties of
Isosteric Substitution in Schiff Base Derivatives
BBMC.F1.20 – In Silico Evaluation of
Tryptamine-Derived Schiff Bases as Modulators of the Serotonin
5-HT2A Receptor
BBMC.F1.21 – Novel Cadmium Dithiocarbamate
Complex
BBMC.F1.22 – Novel Isochromene-Fused
CF3-Substituted Pyrazole Compounds Induce Cytotoxicity through
Caspase Mediated Apoptosis
BBMC.F1.23 – Combination Chemo-Targeting of
NSCLC Cells with Docetaxel and Niclosamide: A Multimodal Cell
Death
BBMC.F1.24 – Synthesis, theoretical analysis,
and HSA/DNA binding activity of the [RuCl2(η6-p-cymene)(bph-κN)]
complex
BBMC.F1.25 – Synthesis and structural
characterization of a new silver(I) complex with miconazole
BBMC.F1.26 – β-Cyclodextrin Inclusion Complex –
In vitro Assessment of the Antioxidant
BBMC.F1.27 – Bioavailability of Selenium
Supplementation: Relevance to Maternal Health and Product
Quality Assessment
BBMC.F1.28 – Selenium-Related Gene Activation
in Fetal Growth Restriction Placentas: A Bioinformatics
Analysis
BBMC.F1.29 – Comparison between mechanochemical
and solution synthesis of
ammonium-iminodiacetatedithiocarbamate
BBMC.F1.30 – Synergistic antibacterial effect
of copper complex and Lythrum salicaria plant extract
BBMC.F1.31 – DNA/BSA interactions of new
gold(III) complexes with some pyridine-containing ligands |
- |
Hall II Chair: Dr. Petar Stanić |
| 12:00 – 12:30 |
Coffee Break
-
|
- | - |
| 12:30 – 13:00 |
Plenary Lecture
Clinical Sciences and Translational Medicine Research Theme at
Coventry University
Abstract: The Clinical Sciences and Translational Medicine (CSTM) theme at Coventry University’s Research Centre for Health and Life Sciences integrates biomedical research, clinical expertise, and technological innovation to address pressing global cardiovascular and metabolic health challenges. Focusing on prevention, early diagnosis, and improved management, the theme’s interdisciplinary research targets conditions including heart failure (HF), type 2 diabetes (T2D), obesity, and related comorbidities. Collaborative projects span local partnerships with University Hospital Coventry and Warwickshire to international networks across Europe, Africa, Asia, and the USA, ensuring clinical relevance and global applicability. Key initiatives include STRATIFYHF, an AI- and computational modelling-based decision support system for HF risk prediction and early diagnosis; the CMB Study, investigating movement behaviours and cardiometabolic health in UK Black adults; BA-Heart, assessing acute cardiovascular effects of beta-alanine supplementation; and the CORS test, enhancing HF diagnostic accuracy in primary care. Additional studies address school-based interventions for disadvantaged children, HRV assessment validity using disposable ECG leads, and a wide range of physiological and clinical investigations. Beyond research, the CSTM fosters academic citizenship through postgraduate training, supervision, and scholarly service, contributing over 50 high-impact publications since 2021. Strategic knowledge transfer is achieved through partnerships with healthcare providers, community organisations, and industry, translating research outcomes into scalable, cost-effective solutions. By combining laboratory discovery with real-world application, CSTM advances scientific understanding, optimises patient outcomes, and builds capacity for future health leaders. This translational framework positions Coventry University as a leading hub for impactful cardiovascular and metabolic research with sustained global influence. |
Prof. Dr. Đorđe Jakovljević, University of Coventry, UK | Hall I Chair: Dr. Igor Saveljić |
| 13:00 – 13:30 |
Plenary Lecture
Computer Simulations as an Important Tool to Develop New Drugs
against SARS-CoV-2
Abstract: Coronaviruses are our everyday companions and are named after crown spikes located on their surface. Sometimes coronaviruses, which usually infect animals, can skip to human hosts. The novel virus (SARS-CoV-2) was reported in December of 2019 to be originating from Wuhan, Hubei China. In the early 2020, the virus spread, causing a global pandemic of COVID-19. Using advanced ensamble molecular docking simulations, followed be extensive molecular dynamics simulations coupled with empirical free-energy calculations we have identified hit compounds against 3CLPRO, PLPRO, and RDRP SARS-CoV-2 protein targets. We have also experimentally confirmed their inhibition with IC50 values in the low μM range. Further experimental verification is essential to validate our computational predictions. |
Prof. Dr. Urban Bren, University of Maribor, Slovenia | Hall I Chair: Dr. Marko Antonijević |
| 13:30 – 14:30 |
Buffet Lunch
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| 14:30 – 15:00 |
Section Lecture
Modulation of thermotropic properties of cholesterol-free model
myelin membranes by myelin basic protein
Abstract: As a continuation of our research on model myelin membranes (MMM), in which we revealed that MMM that mimic normal (healthy) myelin are more fluid at 30 °C than those that mimic modified (diseased) myelin, we aimed to unveil the contribution of cholesterol in MMM thermotropic properties. Accordingly, we prepared MMM as lipid mixtures in the presence and absence of myelin basic protein (MBP), but excluding cholesterol (named MMM’). Using differential scanning calorimetry (DSC) and temperature-dependent UV-Vis spectroscopy, we determined the main phase transition temperature (Tm) of MMM’, i.e., the temperature of the gel-to-fluid phase transition of lipids in MMM’ systems. Besides the discrepancies obtained by these two techniques, we identified a difference of about 5 °C between normal and modified MMM’, independently of MBP. As evidenced by the maintenance and weakening of van der Waals forces at 30 °C and 60 °C, respectively, the fluidity of normal and modified MMM’ is comparable at a corresponding temperature. The modified MMM’ reflected different polar headgroup hydration than normal MMM’ at 30 °C, which is very likely associated with the stabilization of the gel phase in modified MMM’. |
Dr. Danijela Bakarić, Ruđer Bošković Institute, Croatia | Hall I Chair: Dr. Žiko Milanović |
| 14:30 – 15:00 |
Section Lecture
When azoles meet silver: A chemistry power duo against fungi
Abstract: Azole derivatives represent one of the most important classes of antifungal agents, acting as inhibitors of fungal cytochrome P450-dependent lanosterol 14α-demethylase, a key enzyme involved in ergosterol biosynthesis. The coordination of azoles with silver(I) ions has attracted growing attention as the resulting metal complexes can exhibit improved biological activity and therapeutic profiles compared to the parent ligands. This article reports on the synthesis, structural characterization, and biological evaluation of silver(I) complexes with selected azoles used in the treatment of fungal infections (clotrimazole, econazole, and voriconazole). The synthesized complexes were characterized using NMR, IR, and UV-Vis spectroscopy, mass spectrometry, and cyclic voltammetry, while their crystal structures were determined by single-crystal X-ray diffraction analysis. In most cases, the synthesized complexes showed enhanced anti-Candida activity compared to the parent antifungal azoles. Moreover, the corresponding silver(I) complexes demonstrated better activity in preventing hyphae and biofilm formation by C. albicans at subinhibitory concentrations, which is a highly desirable property for a new antimicrobial agent. In addition, these complexes were significantly more effective at inhibiting ergosterol synthesis in the cell membrane of C. albicans at 0.5 × MIC. Taken together, these findings suggest that compounds formed via the complexation of silver(I) ions with antifungal azoles merit further investigation as potential new antifungal agents, offering improved efficacy and safety over clinically used azoles in the treatment of life-threatening Candida infections. |
Prof. Dr. Biljana Glišić, Faculty of Science, University of Kragujevac | Hall II Chair: Doc. Dr. Svetlana Jeremić |
| 15:00 – 16:00 |
Session BAB.F2. Bioinformatics and Applied Biology (Oral session)
BAB.F2.1 – Evaluation of genotoxic potential of
ethyl methanesulfonate in human peripheral blood mononuclear
cells in silico and in vitro
BAB.F2.2 – Investigating protein folding as a
target for neurodegenerative disorders using a biological
activity prediction model based on deep learning
BAB.F2.3 – Effect of Amyloid-beta Exposure on
Phospholipid Dynamics: A Computational and Cellular
Perspective
BAB.F2.4 – Enhanced polyphenolic extraction
efficiency and antioxidant activity of sage using a deep
eutectic solvent based on choline chloride and urea |
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Hall I Chair: Dr. Žiko Milanović |
| 15:00 – 16:00 |
Session AST.F2. Applied Science and Technologies (Oral session)
AST.F2.1 – Transforming the Automotive
Industry: The Role of Artificial Intelligence in Autonomous
Vehicles, Manufacturing, and Urban Mobility
AST.F2.2 – Reflection-mode frequency modulated
photoacoustics of thin Tungsten-based films by novel functional
characterization experimental setup
AST.F2.3 – Smoothed Particle Hydrodynamics
(SPH) for Modelling Microfluidic Flow through 3D Printed Copper
Filters |
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Hall II Chair: Doc. Dr. Svetlana Jeremić |
| 16:00 – 16:30 |
Plenary Lecture
Sleep and the Gut
Abstract: Sustained sleep loss dramatically shortens lifespan, and clinical data link poor sleep with diseases like Diabetes, Alzheimer’s, cardiovascular disease, and cancer. The variety of problems suggests that multiple tissues might be affected, yet most efforts to understand sleep remain focused on the brain. The connection between sleep, health, and life itself remains one of the biggest unsolved biological mysteries. The team’s previous paradigm-shifting work revealed that severe sleep loss leads to high levels of reactive oxygen species (ROS) specifically in the gut, which causes gut damage and can result in early death. The overarching goal of the current work is to explain how sleep loss triggers ROS production, and how the consequent gut oxidation impacts the rest of the body. Using a combination of advanced genetic, genomic, and imaging techniques, the team will build a whole-body framework for understanding the detrimental effects of sleep restriction. |
Prof. Dr. Dragana Rogulja, Harvard Medical School, USA | Hall I Chair: Dr. Jasmina Obradović |
| 16:30 – 17:00 |
Section Lecture
Translational Research: Connecting the Laboratory and the Clinic
Abstract: Translational approaches in cancer research aim to accelerate the transfer of fundamental scientific discoveries into clinical applications, providing a multidisciplinary framework for innovative diagnostics, therapeutic strategies, and preventive interventions. The integration of multi-omics data—encompassing genomic, transcriptomic, proteomic, metabolomic, and epigenomic profiles—offers a robust platform for unraveling the complex molecular landscape of tumors and identifying clinically relevant biomarkers. Patient-derived organoids and cell line models further enhance the predictive power of these analyses by enabling accurate modeling of tumor initiation, progression, and treatment response. Methodologically, mutation, methylation, RNA, and miRNA sequencing data were analyzed using R-based packages including Maftools, DESeq2, ELMER, MultiAssayExperiment, mirNet, and WGCNA, with network visualizations performed in Cytoscape. Over-representation analyses on highly correlated genes/miRNAs from PCA across clinical parameters facilitated the identification of the most statistically discriminative biomarkers. Overall, the validation of multi-omic findings using organoid and cell models significantly enhanced the reliability and efficiency of biomarker research. This integrated approach enables rapid identification and functional validation of predictive and prognostic biomarkers, supporting the development of personalized therapeutic strategies in lung cancer. By linking molecular-level insights to clinically actionable targets, this workflow strengthens translational research and informs precision oncology decision-making. |
Dr. Oğuzhan Akgün, Bursa Uludağ University, Turkey | Hall I Chair: Dr. Jovana Sekulić |
| 16:30 – 17:00 |
Section Lecture
Inverse molecular docking fingerprints for target identification
Abstract: Inverse molecular docking fingerprinting (IMDF) extends classical inverse docking by combining large-scale docking against thousands of experimentally resolved human protein binding sites with a standardized, quantitative representation of ligand–target interaction patterns. Namely, each compound is docked into a comprehensive, highly non-redundant database of protein binding sites and its docking scores are transformed into a multidimensional fingerprint reflecting the binding potential. Similarity between fingerprints can then be quantified and subjected to clustering experiments. This enables the identification of high-scoring potential targets enriched across multiple ligands and distinct groups of compounds sharing comparable binding profiles. Moreover we postulate structural or physicochemical features most likely responsible for target engagement can be effectively inferred. As application examples; drug repurposing against SARS-CoV-2 and binding of phytocannabinoids, IMDF successfully recovered known targets, revealed novel potential therapeutic proteins and clustered chemically diverse ligands into interpretable structural classes reflecting common modes of action. By decoupling ligand clustering from direct chemical similarity, IMDF provides a powerful cheminformatics tool to map chemical space and guide the prioritization of underexplored molecules or scaffolds for follow-up studies. This makes it especially valuable for elucidating mechanisms of action and discovering new protein–ligand interaction profiles. |
Dr. Marko Jukić, University of Maribor, Slovenia | Hall II Chair: Dr. Marko Antonijević |
| 17:00 – 18:00 |
Plenary Lecture
A Multi-Organ-on-a-Chip Platform for Modeling Cancer Metastasis
Abstract: Understanding why certain organs such as heart resist cancer metastasis remains a major challenge in oncology. Here, we present a microphysiological platform capable of modeling multi-organ interactions under dynamic conditions. This system enables investigation of tissue-specific responses to cancer invasion and offers new opportunities for studying organ-selective mechanisms in disease progression. |
Prof. Dr. Milica Radišić, University of Toronto, Canada | Hall I Chair: Dr. Vladimir Simić |
| 17:00 – 18:00 |
GraSPMAT Workshop (Hall II)
Antioxidant and Lipoxygenase Inhibition Activities of
Ultrasound-Assisted Extracts from Prokupac Grape Skins (Section
Lecture)
Biological Potential of Grape Skin Extracts: A Comparative Study of Grape Varieties from the Šumadija Region (Section Lecture)
GRASPMAT.1 – Grape Skin Extract Hydrogel
Restores Systemic Redox Balance in Diabetic Rats
GRASPMAT.2 – Grape Skin Extract–Enriched
Hydrogels for Wound Healing: An Antioxidant-Based Approach
GRASPMAT.3 – Formulation of Alginate–Gelatin
Hydrogels within a Circular Economy Framework: Controlled
Release of Grape Skin Extract via Gelatin Content Modulation
GRASPMAT.4 – Rational Design of Apigenin
Derivatives as Potent Inflammatory Modulators for Improved
Diabetic Wound Healing |
Dr. Dušan Dimić, Associate Professor, University of Belgrade Dr. Sandra Jovičić Milić, Institute for Information Technologies, Kragujevac |
Hall II Chair: Dr. Edina Avdović |
| 18:00 – 18:30 |
Closing Ceremony and Cocktail
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