{"id":20966,"date":"2025-11-14T08:08:48","date_gmt":"2025-11-14T08:08:48","guid":{"rendered":"https:\/\/iit.ac.rs\/?page_id=20966"},"modified":"2026-03-04T09:16:42","modified_gmt":"2026-03-04T09:16:42","slug":"dr-ana-rilak-simovic","status":"publish","type":"page","link":"https:\/\/iit.ac.rs\/en\/dr-ana-rilak-simovic\/","title":{"rendered":"Dr Ana Rilak Simovi\u0107"},"content":{"rendered":"
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\r\n \"\u0434\u0440\r\n <\/div>\r\n\r\n \r\n
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Dr Ana Rilak Simovi\u0107<\/h2>\r\n
\r\n Senior research\nassociate<\/span>\r\n Bioorganic and bioinorganic chemistry<\/span>\r\n <\/div>\r\n\r\n
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Education:<\/b> Doctor of Science - Chemical Sciences<\/div>\r\n
Address:<\/b> Institute of Information Technologies Kragujevac, Liceja Kne\u017eevine Srbije 1A, 34000 Kragujevac<\/div>\r\n
Email:<\/b> anarilak@kg.ac.rs<\/div>\r\n
IBI researcher number:<\/b> AV825<\/div>\r\n <\/div>\r\n\r\n \r\n
\r\n \r\n \"eNauka\"\r\n <\/a>\r\n\r\n \r\n \"SCIDAR\"\r\n <\/a>\r\n\r\n \r\n \"ORCID\"\r\n <\/a>\r\n\r\n \r\n \"ResearchGate\"\r\n <\/a>\r\n\r\n \r\n \"Scopus\"\r\n <\/a>\r\n\r\n \r\n \"LinkedIn\"\r\n <\/a>\r\n <\/div>\r\n\r\n \r\n
\r\n \r\n \ud83d\udcc4<\/span> CV - Serbian\r\n <\/a>\r\n \r\n \ud83d\udcc4<\/span> CV \u2013 English\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n
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\r\n Brief description of the research<\/summary>\r\n
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\r\n Recently, Dr. Ana Rilak Simovi\u0107 has been engaged in the design and synthesis of new ruthenium and gold complexes\nas potential antitumor agents. Gold(III) complexes with chlorophenyl terpyridine\nligands have been synthesized and characterized, as well as ruthenium(II\/III) complexes with Schiff base ligands and polypyridyl ligands.\nResearch includes kinetics and mechanisms of substitution with biomolecules (GMP, L-histidine, L-methionine),\ninteractions of complexes with DNA and human serum albumin, UV-Vis binding analyses, fluorescence spectroscopy,\nviscometry and competitive binding with ethidium bromide and Hoechst 33258.\nAdditionally, the in vitro and in vivo antitumor activity of newly synthesized transition metal complexes is being investigated.\r\n <\/p>\r\n <\/div>\r\n <\/details>\r\n\r\n \r\n

\r\n Selected references<\/summary>\r\n
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  1. \r\n Ana Rilak et al., \r\n New water-soluble Ruthenium(II) terpyridine complexes for anticancer activity: synthesis, characterization, activation kinetics and interaction with guanine derivatives<\/i>, \r\n Inorganic Chemistry<\/b>, 53 (2014) 6113\u20136126. \r\n https:\/\/doi.org\/10.1021\/ic5005215<\/a>\r\n <\/li>\r\n\r\n
  2. \r\n Ana Rilak Simovi\u0107 et al., \r\n Chemistry and reactivity of ruthenium(II) complexes: DNA\/protein binding mode and anticancer activity are related to the complex structure<\/i>, \r\n Coordination Chemistry Reviews<\/b>, 398 (2019) 113011. \r\n https:\/\/doi.org\/10.1016\/j.ccr.2019.07.008<\/a>\r\n <\/li>\r\n\r\n
  3. \r\n Dejan Lazi\u0107 et al., \r\n New bis-pyrazolylpyridine ruthenium(III) complex as a potential anticancer drug: In vitro and in vivo activity in murine colon cancer<\/i>, \r\n Dalton Transactions<\/b>, 50 (2021) 7686\u20137704. \r\n https:\/\/doi.org\/10.1039\/D1DT00185J<\/a>\r\n <\/li>\r\n\r\n
  4. \r\n Radisavljevi\u0107 et al., \r\n New gold(III) chlorophenyl terpyridine complex: Biomolecular interactions and anticancer activity against human oral squamous cell carcinoma<\/i>, \r\n Applied Organometallic Chemistry<\/b>, 2023, e6922. \r\n https:\/\/doi.org\/10.1002\/aoc.6922<\/a>\r\n <\/li>\r\n\r\n
  5. \r\n Me\u0111edovi\u0107 et al., \r\n Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes<\/i>, \r\n Journal of Inorganic Biochemistry<\/b>, 248 (2023) 112363. \r\n https:\/\/doi.org\/10.1016\/j.jinorgbio.2023.112363<\/a>\r\n <\/li>\r\n\r\n <\/ol>\r\n <\/div>\r\n <\/details>\r\n\r\n <\/div>\r\n <\/div>\r\n<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

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