{"id":21079,"date":"2025-11-14T10:02:20","date_gmt":"2025-11-14T10:02:20","guid":{"rendered":"https:\/\/iit.ac.rs\/?page_id=21079"},"modified":"2026-03-04T09:28:47","modified_gmt":"2026-03-04T09:28:47","slug":"dr-ana-kesic","status":"publish","type":"page","link":"https:\/\/iit.ac.rs\/en\/dr-ana-kesic\/","title":{"rendered":"Dr Ana Kesi\u0107"},"content":{"rendered":"
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\r\n \"\u0434\u0440\r\n <\/div>\r\n\r\n \r\n
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Dr Ana Kesi\u0107<\/h2>\r\n\r\n
\r\n Senior research\nassociate<\/span>\r\n Bioorganic and bioinorganic chemistry<\/span>\r\n <\/div>\r\n\r\n
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Education:<\/b> Doctor of Science - Chemical Sciences<\/div>\r\n
Address:<\/b> Institute of Information Technology Kragujevac, Jovana Cviji\u0107a bb, 34000 Kragujevac.<\/div>\r\n
Email:<\/b> akesic@uni.kg.ac.rs<\/div>\r\n
IBI (Researcher Identification Number):<\/b> BA368<\/div>\r\n <\/div>\r\n\r\n \r\n
\r\n\r\n \r\n \"eNauka\"\r\n <\/a>\r\n\r\n \r\n \"SCIDAR\"\r\n <\/a>\r\n\r\n \r\n \"ORCID\"\r\n <\/a>\r\n\r\n \r\n \"ResearchGate\"\r\n <\/a>\r\n\r\n \r\n \"Scopus\"\r\n <\/a>\r\n\r\n <\/div>\r\n\r\n \r\n
\r\n\r\n \r\n \ud83d\udcc4<\/span> CV - Serbian\r\n <\/a>\r\n\r\n \r\n \ud83d\udcc4<\/span> CV \u2013 English\r\n <\/a>\r\n\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n \r\n
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\r\n Brief description of the research<\/summary>\r\n\r\n
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\r\n Research is focused on the synthesis and detailed characterization of mononuclear complexes of transition metal ions, primarily gold, silver and copper, which exhibit potential antitumor activity. The newly obtained complexes are structurally confirmed using advanced analytical techniques, including NMR, IR and UV\u2013Vis spectroscopy, mass spectrometry and X-ray structural analysis. Special emphasis is placed on studying the kinetics and mechanisms of substitution reactions of these compounds with biologically relevant molecules, such as amino acids, peptides and DNA fragments, using spectrophotometric techniques. In addition, the interactions of the complexes with DNA molecules and serum albumin proteins are studied using a combination of experimental and computational methods, with the aim of better understanding their biological behavior. The therapeutic potential of the complexes is assessed by testing their cytotoxic activity on selected tumor cell lines in vitro. In addition to metal complexes, a significant part of the research includes the green synthesis of nanoparticles of silver and other metals using plant extracts as environmentally friendly reducing and stabilizing agents. The nanoparticles are characterized by spectroscopic, diffraction and microscopic methods, and their potential biological activity is examined in the context of antimicrobial, antioxidant and antitumor properties.\r\n <\/p>\r\n <\/div>\r\n\r\n <\/details>\r\n\r\n \r\n

\r\n Selected references<\/summary>\r\n\r\n
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  1. \r\n Sne\u017eana Radisavljevi\u0107, Ana Kesi\u0107, Du\u0161an \u0106o\u0107i\u0107, Vladimir Markovi\u0107, Jelena Milovanovi\u0107,\r\n Biljana Petrovi\u0107, Ana Rilak Simovi\u0107,\r\n New gold(III) chlorophenyl terpyridine complex: Biomolecular interactions and anticancer activity against human oral squamous cell carcinoma<\/i>,\r\n Applied Organometallic Chemistry, 2023, Vol. 37, Issue 1,\r\n DOI: 10.1002\/aoc.6922.\r\n
    \r\n \r\n https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/aoc.6922\r\n <\/a>\r\n<\/li>\r\n\r\n
  2. \r\n Sne\u017eana Radisavljevi\u0107, Ana \u0110ekovi\u0107 Kesi\u0107, Du\u0161an \u0106o\u0107i\u0107, Rainer Puchta, Lothar Senft,\r\n Milica Milutinovi\u0107, Neboj\u0161a Milivojevi\u0107, Biljana Petrovi\u0107,\r\n Transition metal complexes with ferrocene-based ligands: Synthesis and characterization<\/i>,\r\n New Journal of Chemistry, 2020, Vol. 44, Issue 14, p. 1172,\r\n DOI: 10.1039\/D0NJ02037K.\r\n
    \r\n     \r\n https:\/\/doi.org\/10.1039\/D0NJ02037K\r\n <\/a>\r\n<\/li>\r\n\r\n
  3. \r\n \u017deljko Milanovi\u0107, Zoran Markovi\u0107, Ana Kesi\u0107, Sne\u017eana Jovanovi\u0107 Stevi\u0107, Biljana Petrovi\u0107,\r\n Elma Avdovi\u0107,\r\n Gold(I) and Copper(I) complexes: Synthesis, structural characterization, and biological evaluation<\/i>,\r\n Dalton Transactions, 2024, Vol. 53, p. 8275,\r\n DOI: 10.1039\/D4DT00789A.\r\n
    \r\n     \r\n https:\/\/doi.org\/10.1039\/D4DT00789A\r\n <\/a>\r\n<\/li>\r\n\r\n
  4. \r\n Katarina Markovi\u0107, Ana Kesi\u0107, Marija Novakovi\u0107, Marija Grujovi\u0107, Du\u0161an Simijonovi\u0107,\r\n Elma Avdovi\u0107, Sa\u0161a Mati\u0107, Milan Paunovi\u0107, Milica Milutinovi\u0107, Du\u0161an Nikodijevi\u0107,\r\n Oliver Stefanovi\u0107, Zoran Markovi\u0107,\r\n Advances in transition metal chemistry: New insights into bioactive complexes<\/i>,\r\n RSC Advances, 2024, Vol. 14, p. 4591,\r\n DOI: 10.1039\/D3RA07819A.\r\n
    \r\n     \r\n https:\/\/doi.org\/10.1039\/D3RA07819A\r\n <\/a>\r\n<\/li>\r\n\r\n
  5. \r\n Ana Kesi\u0107, Sne\u017eana Jeremi\u0107, Biljana Petrovi\u0107,\r\n Coordination chemistry studies of transition metal complexes<\/i>,\r\n Journal of Coordination Chemistry, 2024, Vol. 17, p. 653,\r\n DOI: 10.1080\/00958972.2023.2296382.\r\n
    \r\n     \r\n https:\/\/doi.org\/10.1080\/00958972.2023.2296382\r\n <\/a>\r\n<\/li>\r\n\r\n <\/ol>\r\n <\/div>\r\n\r\n <\/details>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n<\/div>\r\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

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