Dr Dejan Milenković

Dr. Dejan Milenković is engaged in the investigation of the mechanisms of antiradical action of natural compounds towards free radical species by applying thermodynamic and kinetic approaches. Structure-activity relationships towards biologically important reactive oxygen species (•OH, •OOH, O₂•⁻, аскорбил, хлоровани метилперокси) и реактивним азотовим врстама (NO•), као и према модел радикалима (DPPH, ABTS). Анализирају се механизми HAT, RAF, HAA-RAF, RAF-HAA, SPLET и SET-PT у различитим растварачима; на основу термодинамичких и кинетичких параметара одређује се доминантан механизам и брзина деактивације радикала. Поред тога, врше се симулације молекулског докинга и изграђују QSAR модели за одабрана природна једињења.

1. Dejan Milenković, Jelena Đorović, Vladimir Petrović, Edina Avdović, Zoran Marković, Hydrogen atom transfer versus proton coupled electron transfer mechanism of gallic acid with different peroxy radicals, Reaction Kinetics, Mechanisms and Catalysis, 123, 215–230, 2018. https://doi.org/10.1007/s11144-017-1286-8
2. Dejan Milenković, Dušan Dimić, Edina Avdović, Ana Amić, Jasmina Dimitrić-Marković, Zoran Marković, Advanced oxidation process of coumarins by hydroxyl radical: Towards the new mechanism leading to less toxic products, Chemical Engineering Journal, 395, 124971, 2020. https://doi.org/10.1016/j.cej.2020.124971
3. Dušan Dimić, Dejan Milenković, Edina Avдовић, Đura Nakarada, Jasmina Dimitrić-Marković, Zoran Marković, Advanced oxidation processes of coumarins by hydroperoxyl radical: An experimental and theoretical study, and ecotoxicology assessment, Chemical Engineering Journal, 424, 130331, 2021. https://doi.org/10.1016/j.cej.2021.130331
4. Dejan Milenković, Dušan Dimić, Edina Avdović, Dušica Simijonović, Radiša Vojиновић, Zoran Marković, A thermodynamic and kinetic HO radical scavenging study and protein binding of baicalein, Journal of Chemical Thermodynamics, 185, 107110, 2023. https://doi.org/10.3390/app13052984
5. Petar Stanić, Biljana Šmit, Dejan Milenković, Kinetics and mechanism of amino acid derived 2-thiohydanoin formation reactions, Reaction Chemistry & Engineering, 2023 (Accepted Manuscript). https://doi.org/10.1039/D2RE00423B