Brief description of the research
The research focus is on the development of computer models applied in the field of bioengineering (development of mathematical models and their numerical solution). Models developed so far include a model of the heart (ablation), coronary and carotid arteries (plaque development), middle and inner ear (hearing and balance), biomaterial testing and the concept of organs on chips (lungs, liver), a model of fibrous heart microtissue, as well as a model of the kidney (polarization of renal epithelial cells).
Numerical methods can be continuous and discrete, while models are solved at different scales (micro, meso, macro) depending on the research needs. Recent research has focused on the field of regenerative medicine, where computer models can significantly advance the development of new regenerative strategies and accelerate the path to preclinical and clinical testing.
Selected references
- Ignasi Jorba, Milica Nikolic, Carlijn VC Bouten, Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration, Chapter 8, у књизи *Cardiac and Vascular Biology*, Springer (у штампи).
- Filipovic N., Nikolic M., Sustersic T., Simulation of organ-on-a-chip systems, Chapter 28 у књизи *Biomaterials for Organ and Tissue Regeneration*, 2020, pp. 753–790. DOI: 10.1016/B978-0-008-102906-0.00028-3
- Nikolic M., Sustersic T., Filipovic N., In vitro models and on-chip systems: Biomaterial interaction studies with tissues generated using lung epithelial and liver metabolic cell lines, Frontiers in Bioengineering and Biotechnology, Vol. 6, 2018. DOI: 10.3389/fbioe.2018.00120
- Šušteršič T., Simsek G.M., Yapici G.G., Nikolić M., Vulović R., Filipovic N., Engin Vrana N., An In-Silico Corrosion Model for Biomedical Applications…, Frontiers in Bioengineering and Biotechnology, 2021. DOI: 10.3389/fbioe.2021.718026
- Vulovic R., Nikolic M., Filipovic N., Smart Platform for the Analysis of Cupula Deformation caused by Otoconia Presence within SCCs, Computer Methods in Biomechanics and Biomedical Engineering, Vol. 22(2), 2019. DOI: 10.1080/10255842.2018.1539166