Momčilo Prodanović
Brief description of the research
Momčilo Prodanović's research includes the development of computer models of biophysical systems and tissues at different temporal and spatial scales, in close connection with available experimental data.
In recent years, he has placed special focus on the mechanisms of muscle contraction, as well as on the analysis of the impact of cardiovascular genetic diseases and drugs on heart muscle function.
Participates in the development of biophysically realistic muscle models and simulation platforms such as:
MUSICO – платформа за симулацију мишићних контракција
MUSICO-X – software for interpreting X-ray diffraction images of living muscle fibers
Selected references
- Filipovic N., Sustersic T., Milosevic M., Milicevic B., Simic V., Prodanovic M., Mijailovic S., Kojic M. (2022): SILICOFCM platform, multiscale modeling of left ventricle from echocardiographic images and drug influence for cardiomyopathy disease, Computer Methods and Programs in Biomedicine, 227, 107194. DOI: 10.1016/j.cmpb.2022.107194.
- Prodanovic M., Geeves M. A., Poggesi C., Regnier M., Mijailovich S.M. (2022): Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans, International Journal of Molecular Sciences, 23(3), 1135. DOI: 10.3390/ijms23031135.
- Mijailovich S.M., Prodanovic M., Poggesi C., Powers J.D., Davis J., Geeves M.A., Regnier M. (2021): The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions, Journal of Molecular and Cellular Cardiology, 155, 112–124. DOI: 10.1016/j.yjmcc.2021.02.009.
- Mijailovich S.M., Prodanovic M., Poggesi C., Geeves M.A., Regnier M. (2021): Multiscale Modeling of Twitch Contractions in Cardiac Trabeculae, Journal of General Physiology, 153(3), e202012604. DOI: 10.1085/jgp.202012604.
- Mijailovich S.M., Prodanovic M., Irving T.C. (2019): Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data, International Journal of Molecular Sciences, 20(23), 6044. DOI: 10.3390/ijms20236044.
