Dr Nenad Janković

The research interest of Dr. Nenad Janković is focused on the development of green and sustainable methods of organic synthesis, primarily for the preparation of Biginelli, as well as quinoxolinone, benzoxazinone and benzylidene derivatives. All obtained derivatives were subjected to pharmacological and biological testing, whereby the most active compounds against certain tumors were identified, which are currently in the preliminary stages of preclinical testing. The second part of the research relates to the synthesis and application of pharmacologically active ionic liquids. In the following projects, the synthesis of a library of tetrahydropyrimidines as potential inhibitors of specific biological targets is planned.

1. N. Janković et al., Water-tuned tautomer-selective tandem synthesis of the 5,6-Dihydropyrimidin-4(3H)-ones, driven under the umbrella of sustainable chemistry, ACS Sustainable Chemistry & Engineering, 2018, 6(10):13358–13366.
2. N. Janković et al., Discovery of the Biginelli hybrids as novel caspase-9 activators in apoptotic machines: lipophilicity, molecular docking study, influence on angiogenesis gene and miR-21 expression levels, Bioorganic Chemistry, 2019, 86:569–582.
3. N. Janković et al., A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities, Chemico-Biological Interactions, 2022, 363:110025.