Dr Sanja Matić

Dr. Sanja Matić has made significant scientific contributions in the field of Biology, especially Genetics and Genotoxicology. Her research was focused in two directions: the first relates to the investigation of potential genotoxic activity, i.e. the ability of agents of natural (plant extracts) and artificial origin (selected secondary plant metabolites) to induce DNA damage in vitro and in vivo conditions; while the second is aimed at testing the protective activity of biologically active substances in germinal and/or somatic cells in organisms of different organizational levels in in vitro and in vivo conditions. Testing the in vitro antigenotoxic activity of plant extracts and selected pure components aims to detect the degree of DNA protection after damage induced by hydroxyl and peroxyl radicals, which encourages further research and their potential use for nutritional and/or pharmacological purposes. After testing methanol extracts and components in conditions that simulate physiological conditions, i.e. In vitro, genotoxic activity and DNA protective potential were examined in vivo using a test for the detection of sex-linked recessive lethal mutations in the eukaryotic model organism D. melanogaster and the Comet test in D. melanogaster and Wistar rat strains with the aim of obtaining results that would most closely reflect the physiological significance of the tested agents.

1. Milan Mladenović, Nevena Stanković, Sanja Matić, Snežana Stanić, Mirjana Mihailović, Vladimir Mihailović, Jelena Katanić, Tatjana Boroja, Nenad Vuković, Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIa: A story behind the molecular modeling approach, Biochemical Pharmacology, (2015), vol. 98, str. 243–266. ISSN: 0006-2952. IF2015 = 5.091, M21a. DOI: 10.1016/j.bcp.2015.08.106
2. Sanja Matić, Jelena Katanić, Snežana Stanić, Milan Mladenović, Nevena Stanković, Vladimir Mihailović, Tatjana Boroja, In vitro and in vivo assessment of the genotoxicity and antigenotoxicity of the Filipendula hexapetala and Filipendula ulmaria methanol extracts, Journal of Ethnopharmacology, (2015), vol. 174, str. 287–292. ISSN: 0378-8741. IF2015 = 3.055, M21a. DOI: 10.1016/j.jep.2015.08.025
3. Sanja Matić, Snežana Stanić, Mirjana Mihailović, Desanka Bogojević, Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential, Saudi Journal of Biological Sciences, (2016), vol. 23, str. 452–461. ISSN: 1319-562X. IF2016 = 2.564, M21. DOI: 10.1016/j.sjbs.2015.05.012
4. Nikola Stanković, Ivana Kostić, Boris Jovanović, Dimitrija Savić-Zdravković, Sanja Matić, Jelena Bašić, Tatjana Cvetković, Jelica Simeunović, Djuradj Milošević, Can phytoplankton blooming be harmful to benthic organisms? The toxic influence of Anabaena sp. and Chlorella sp. on Chironomus riparius larvae, Science of The Total Environment, (2020), vol. 729, str. 138666. IF2020 = 7.963. DOI: 10.1016/j.scitotenv.2020.138666
5. Milena Vukić, Nenad Vuković, Milan Mladenović, Nevena Tomašević, Sanja Matić, Snežana Stanić, Filippo Sapienza, Rino Ragno, Mijat Božović, Miroslava Kacániová, Chemical composition of various Nepeta cataria plant organs’ methanol extracts associated with in vivo hepatoprotective and antigenotoxic features as well as molecular modeling investigations, Plants, (2022), vol. 11, str. 2114. IF2021 = 4.658, M21a. DOI: 10.3390/plants11162114