Dr Jelena Đorović Jovanović
Brief description of the research
The research in which the candidate participated can be classified into two closely related groups according to the topic and methodology. First, Jelena Đorović Jovanović's research work was focused on examining the structure and antioxidant activity of natural phenolic compounds, while she further examined the antioxidant and pro-oxidative properties of synthetic phenolic compounds - Schiff bases and their complexes with metals. Later research work was focused on examining the antioxidant activity of natural and synthetic compounds, as well as examining their interaction with proteins. Current research includes examining the inhibitory capacity of various compounds (antioxidants and drugs) and their interactions with proteins. Molecular docking and molecular dynamics simulations are used to study protein-ligand interactions.
Selected references
- Dušan S. Dimić, Zoran S. Marković, Luciano Saso, Edina H. Avdović, Jelena R. Đorović, Isidora P. Petrović, Danijela D. Stanisavljević, Milena J. Stevanović, Ivan Potočňák, Erika Samoľová, and Srećko R. Trifunović, Synthesis and Characterization of 3-(1-((3, 4-Dihydroxyphenethyl) amino) ethylidene)-chroman-2, 4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity 2019, 2019, 2069250. https://doi.org/10.1155/2019/2069250.
- Jelena Đorović, Dejan Milenković, Ljubinka Joksović, Milan Joksović, Zoran Marković, Study of influence of free radical species on antioxidant activity of selected 1,2,4-triazole-3-thiones. ChemistrySelect, 2019, 4, 7476-7485. https://doi.org/10.1002/slct.201900895.
- Jelena Đorović Jovanović, Marko Antonijević, Ali A El‐Emam, Zoran Marković, Comparative MD Study of Inhibitory Activity of Opaganib and Adamantane‐Isothiourea Derivatives toward COVID‐19 Main Protease Mpro, ChemistrySelect, 2021, 6, 8603-8610. https://doi.org/10.1002/slct.202101898.
- Nenad Janković, Emilija Milović, Jelena Đorović Jovanović, Zoran Marković, Milan Vraneš, Tatjana Stanojković, Ivana Matić, Marija Đorđić Crnogorac, Olivera Klisurić, Miroslav Cvetinov, Syed Nasir Abbas Bukhariff, A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities. Chemico-biological interactions, 2022, 363, 110025. https://doi.org/10.1016/j.cbi.2022.110025.
- Jelena Đorović Jovanović, Marko Antonijević, Radiša Vojинović, Nenad D. Filipović and Zoran Marković, In silico study of inhibitory capacity of sacubitril/valsartan toward neprilysin and angiotensin receptor. RSC Advances, 2022, 12, 29719-29726. https://doi.org/10.1039/D2RA04226F.