Dr Žiko Milanović

Dr. Žiko Milanović's research is focused on examining and defining the mechanisms of antioxidant activity of various polyphenolic compounds using modern spectroscopic (EPR, DPPH, ABTS, FRAP, CUPRAC) and computational methods.

In addition, he is engaged in the analysis of structural properties of molecules (NBO, QTAIM) to determine reactivity and stability, as well as the application of molecular docking and molecular dynamics to assess inhibitory activity and rational drug design.

The use of computational tools allows predicting the binding modes of newly synthesized compounds to target proteins and defining their therapeutic potential.

1. Žiko Milanović, Dušan Dimić, Marko Antonijević, Milan Žižić, Dejan Milenković, Edina Avdović, Zoran Marković, Influence of acid-base equilibria on the rate of the chemical reaction in the advanced oxidation processes: Coumarin derivatives and hydroxyl radical, Chemical Engineering Journal, 453 (2023) 139648. DOI: 10.1016/j.cej.2022.139648
2. Žiko Milanović, Dušan Dimić, Milan Žižić, Zoran Marković, Edina Avdović, Mechanism of antiradical activity of newly synthesized 4,7-dihydroxycoumarin derivatives – experimental and kinetic DFT study, International Journal of Molecular Sciences, 22 (24), 2021. DOI: 10.3390/ijms222413273
3. Žiko Milanović, Marko Antonijević, Ana Amić, Edina Avdović, Dušan Dimić, Dejan Milenković, Zoran Marković, Inhibitory activity of quercetin, its metabolite, and antiviral drugs toward SARS-CoV-2 essential enzymes, RSC Advances, 11 (2021), 2838–2847. DOI: 10.1039/d0ra09632f
4. Žiko Milanović, Jelena Tošović, Svetlana Marković, Zoran Marković, Comparison of scavenging capacities of phloroglucinol and 2,4,6-trihydroxypyridine toward HO˙ radical, RSC Advances, 10 (2020), 43262–43272. DOI: 10.1039/d0ra08377a
5. Žiko Milanović, Structural properties of newly 4,7-dihydroxycoumarin derivatives as potential coagulation factor inhibitors, Journal of Molecular Structure, 1298 (2024), 137049. DOI: 10.1016/j.molstruc.2023.137049