Dr Dušica Simijonović
Brief description of the research
The main part of the research includes the synthesis of potentially biologically active organic and organometallic compounds. The synthesized compounds belong to the group of phenolic Schiff and Mannich bases, coumarin derivatives, as well as the group of nitrogen heterocyclic molecules that contain a piperidine, pyrazolone, pyrazole or pyrazolo-phthalazine unit in their structure – and often a phenolic part.
The syntheses are realized using "green organic synthesis tools". Structural characterization is carried out using various experimental and theoretical techniques. A significant segment of research relates to the determination of the antioxidant and anti-inflammatory activities of these compounds using various in vitro tests.
Selected references
- Dušica M. Simijonović, Dejan A. Milenković, Edina H. Avdović, Žiko B. Milanović, Marko R. Antonijević, Ana D. Amić, Zana Dolićanin, Zoran S. Marković, Coumarin N-Acylhydrazone Derivatives: Green Synthesis and Antioxidant Potential—Experimental and Theoretical Study, Antioxidants, 2023. DOI: 10.3390/antiox12101858
- Marko R. Antonijević, Dušica M. Simijonović, Edina H. Avdović, Andrija Ćirić, Zorica D. Petrović, Jasmina Dimitрић Marković, Višnja Stepanić, Zoran S. Marković, Green One-Pot Synthesis of Coumarin-Hydroxybenzohydrazide Hybrids and Their Antioxidant Potency, Antioxidants, 2021, 10, 1106. DOI: 10.3390/antiox10071106
- Dušica Simijonović, Evangelia-Eirini Vlachou, Zorica D. Petrović, Dimitra J. Hadjipavlou-Litina, Konstantinos E. Litinas, Nevena Stanković, Nezrina Mihović, Milan P. Mladenović, Dicoumarol derivatives: Green synthesis and molecular modelling studies of their anti-LOX activity, Bioorganic Chemistry, 2018, 80, 741–752. DOI: 10.1016/j.bioorg.2018.07.021
- Vesna M. Milovanović, Zorica D. Petrović, Slađana Novaković, Goran A. Bogdanović, Vladimir P. Petrović, Dušica Simijonović, Green synthesis of benzamide-dioxoisoindoline derivatives and assessment of their radical scavenging activity, Tetrahedron, 2020, 76, 131456. DOI: 10.1016/j.tet.2020.131456
- Dušica Simijonović, Zorica D. Petrović, Vesna M. Milovanović, Vladimir P. Petrović, Goran A. Bogdanović, A new efficient domino approach for the synthesis of pyrazolyl-phthalazine-diones. Antiradical activity of novel phenolic products, RSC Advances, 2018, 8, 16663–16673. DOI: 10.1039/c8ra02702a