Dr Jelena Košarić
Brief description of the research
Investigation of the molecular mechanisms of the influence of organoselen compounds (OSCs) on the redox status of immortalized HCT-116 colon carcinoma and MDA-MB-231 breast carcinoma cell lines.
Examination of the effects of OSJ on the migratory potential of HCT-116 and MDA-MB-231 cells using the Transwell migration assay.
Determination of the influence of OSJ on the expression of mRNA target genes for seleno-enzymes in HCT-116 cells by quantitative PCR.
Examination of the effects of OSJ on the activity of the transcription factors Nrf2, HIF and NF-κB, as well as their interrelationships, using fluorescent methodology, transfection of the pTRAF vector and analysis on the Operetta system at single-cell resolution.
Selected references
- Živanović MN, Košarić JV, Šmit BM, Šeklić DS, Pavlović RZ, Marković SD. Novel seleno-hydantoin palladium (II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells. General Physiology and Biophysics, 2017, 36(2): 187–196.
- Čanović PP, Bogojevski JV, Košarić JV, Marković SD, Živanović MN. Pt (IV), Pd (II), and Rh (III) complexes induced oxidative stress and cytotoxicity in the HCT-116 colon cancer cell line. Turkish Journal of Biology, 2017, 41(1): 141–147.
- Košarić JV, Cvetković DM, Živanović MN, Ćurčić MG, Šeklić DS, Bugarčić ZM, Marković SD. Antioxidative and antiproliferative evaluation of 2-(phenylselenomethyl)tetrahydrofuran and 2-(phenylselenomethyl)tetrahydropyran. J BOUN, 2014, 19(1): 283–290.
- Petrović VP, Simijonović D, Živanović MN, Košarić JV, Petrović ZD, Marković S, Marković SD. Vanillic Mannich bases: synthesis and screening of biological activity... RSC Advances, 2014, 4(47): 24635–24644.
- Živanović MN, Cvetković DM, Košarić JV, Ćurčić MG, Šeklić DS, Bugarčić ZM, Marković SD. Antioxidative effects of novel selenium compounds. FEBS Journal, 2012, 279(1): 197–197.