Dr Biljana Šmit

Research belongs to the field of bioorganic, bioinorganic and medicinal chemistry. The kinetics and mechanisms of formation reactions, as well as interactions with biomolecules are investigated using various spectroscopic methods (NMR, UV-Vis, fluorimetry) and theoretical (DFT, docking) methods. Within bioorganic chemistry, research is directed towards the synthesis, characterization and testing of various biologically active heterocyclic compounds and their molecular hybrids with natural substances. Within bioinorganic chemistry, complexes of transition metal ions are investigated as antitumor agents, their cytotoxic activity and mechanisms of action.

1. Biljana Šmit, Radoslav Z. Pavlović, Three-step synthetic pathway to fused bicyclic hydantoins involving a selenocyclization step, Tetrahedron, 2015, 71:1101–1108. https://doi.org/10.1016/j.tet.2014.12.088
2. Biljana Šmit, Marko Rodić, Radoslav Z. Pavlović, Synthesis of angularly fused (homo)triquinane type hydantoins as precursors of bicyclic α-prolines, Synthesis (Stuttgart), 2016, 48:387–393. https://doi.org/10.1055/s-0035-1561285
3. Tanja V. Soldatović, Enisa Selimović, Nevena Milivojević, Milena Jovanović, Biljana Šmit, Novel heteronuclear Pt(II)-L-Zn(II) complexes…, Applied Organometallic Chemistry, 2020, e5864. https://doi.org/10.1002/aoc.5864
4. Snežana Jovanović-Stević et al., including Biljana Šmit, Bis(triazinyl)pyridine complexes of Pt(II) and Pd(II)…, Journal of Biological Inorganic Chemistry, 2021, 26:625–637. https://doi.org/10.1007/s00775-021-01879-3
5. Petar Stanić, Biljana Šmit, Dejan Milenković, Kinetics and mechanism of amino acid derived 2-thiohydanoin formation reactions, Reaction Chemistry & Engineering, 2023. https://doi.org/10.1039/D2RE00423B