Dr Emina Mrkalić
Senior research
associate
Bioorganic and bioinorganic chemistry
Brief description of the research
Research includes:
а) Determining structural changes during the binding of commercial drugs to certain blood plasma proteins, as well as examining the specificity of drug-protein interactions in simulated physiological conditions.
б) Testing the interactions of newly synthesized compounds with human serum proteins and a DNA molecule (calf DNA). Binding constants, binding sites, thermodynamic parameters and the nature of the forces involved in binding are determined.
In this way, binding constants will be determined, as well as binding sites, thermodynamic parameters, and the nature of binding forces between the drug/newly synthesized compounds and proteins.
Selected references
- Emina M. Mrkalić, Ratomir M. Jelić, Olivera R. Klisurić, Zoran D. Matović, Synthesis of novel palladium(II) complexes with oxalic acid diamide derivatives and their interaction with nucleosides and proteins, Dalton Transactions, 43 (2014) 15126–15137. https://doi.org/10.1039/C3DT53384K.
- Emina Mrkalić, Ratomir Jelić, Stefan Stojanović, Miroslav Sovrlić, Interaction between olanzapine and human serum albumin and effect of metal ions, caffeine and flavonoids on the binding: A spectroscopic study, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 249 (2021) 119295. https://doi.org/10.1016/j.saa.2020.119295.
- Miroslav Sovrlić, Emina Mrkalić, Ratomir Jelić, Marina Ćendić Serafinović, Stefan Stojanović, Nevena Prodanović, Jovica Tomović, Effect of caffeine and flavonoids on the binding of tigecycline to human serum albumin: A spectroscopic study and molecular docking, Pharmaceuticals, 15(3) (2022) 266. https://doi.org/10.3390/ph15030266.